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1

Linaclotide, through activation of guanylate cyclase C, acts locally in the gastrointestinal tract to elicit enhanced intestinal secretion and transit

Robert W. Busby, Alexander P. Bryant, Wilmin P. Bartolini, Etchell A. Cordero, Gerhard Hannig, Marco M. Kessler, Shalina Mahajan-Miklos, Christine M. Pierce, Robert M. Solinga, Li Jing Sun, Jenny V. T

Journal:

European Journal of Pharmacology

Year:

2010

Language:

english

File:

PDF, 804 KB

english, 2010

2

Strategies for optimizing heterologous protein expression in Escherichia coli

Gerhard Hannig, Savvas C Makrides

Journal:

Trends in Biotechnology

Year:

1998

Language:

english

File:

PDF, 101 KB

english, 1998

3

Detection of Epstein-Barr virus small RNAs EBER1 and EBER2 in lymphomas of SIV-infected rhesus monkeys by in situ hybridization

Sabine Pingel, Horst Hannig, Kerstin Mätz-Rensing, Franz-Josef Kaup, Gerhard Hunsmann, Walter Bodemer

Journal:

International Journal of Cancer

Year:

1997

Language:

english

File:

PDF, 231 KB

english, 1997

4

Elevated serum level of soluble CD23 precedes development of B-non-Hodgkin's lymphoma in SIV-infected rhesus monkeys

Horst Hannig, Christian Buske, Kerstin Mätz-Rensing, Gerhard Hunsmann, Wolfgang Hiddemann, Walter Bodemer

Journal:

International Journal of Cancer

Year:

1998

Language:

english

File:

PDF, 193 KB

english, 1998

5

Suppression of inflammation and structural damage in experimental arthritis through molecular targeted therapy with PPI-2458

Gerhard Hannig, Sylvie G. Bernier, Jennifer G. Hoyt, Beth Doyle, Ed Clark, Russell M. Karp, Jeanine Lorusso, William F. Westlin

Journal:

Arthritis & Rheumatism

Year:

2007

Language:

english

File:

PDF, 233 KB

english, 2007

6

Methionine aminopeptidases type I and type II are essential to control cell proliferation

Sylvie G. Bernier, Nazbeh Taghizadeh, Charles D. Thompson, William F. Westlin, Gerhard Hannig

Journal:

Journal of Cellular Biochemistry

Year:

2005

Language:

english

File:

PDF, 237 KB

english, 2005

7

Expression of the simian epstein-barr virus-encoded latent membrane protein-1 in malignant lymphomas of SIV-infected rhesus macaques

Sabine Blaschke, Horst Hannig, Christian Buske, Franz-J. Kaup, Gerhard Hunsmann, Walter Bodemer

Journal:

Journal of Medical Virology

Year:

2001

Language:

english

File:

PDF, 459 KB

english, 2001

8

Synthesis and evaluation of alkoxy-phenylamides and alkoxy-phenylimidazoles as potent sphingosine-1-phosphate receptor subtype-1 agonists

Ghotas Evindar, Sylvie G. Bernier, Malcolm J. Kavarana, Elisabeth Doyle, Jeanine Lorusso, Michael S. Kelley, Keith Halley, Amy Hutchings, Albion D. Wright, Ashis K. Saha, Gerhard Hannig, Barry A. Morg

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 169 KB

english, 2009

9

Exploration of amino alcohol derivatives as novel, potent, and highly selective sphingosine-1-phosphate receptor subtype-1 agonists

Ghotas Evindar, Sylvie G. Bernier, Elisabeth Doyle, Malcolm J. Kavarana, Alexander L. Satz, Jeanine Lorusso, Heather S. Blanchette, Ashis K. Saha, Gerhard Hannig, Barry A. Morgan, William F. Westlin

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 695 KB

english, 2010

10

Team Work in Protein Processing

Journal:

Chemistry & Biology

Year:

2007

Language:

english

File:

PDF, 191 KB

english, 2007

11

Formation of chiral ionic liquids and imidazol-2-ylidene metal complexes from the proteinogenic aminoacid l-histidine

Frithjof Hannig, Gerald Kehr, Roland Fröhlich, Gerhard Erker

Journal:

Journal of Organometallic Chemistry

Year:

2005

Language:

english

File:

PDF, 628 KB

english, 2005

12

Conformational features of a furyl-substituted bis(tetrahydroindenyl)zirconium dichloride system

Thorsten Dreier, Frithjof Hannig, Gerhard Erker, Klaus Bergander, Roland Fröhlich

Journal:

Journal of Physical Organic Chemistry

Year:

2002

Language:

english

File:

PDF, 146 KB

english, 2002

13

Comparison of the biochemical and biological functions of tyrosine phosphatases from fission yeast, budding yeast and animal cells

Gerhard Hannig, Sabine Ottilie, Andrea R. Schievella, Raymond L. Erikson

Journal:

Year:

1993

Language:

english

File:

PDF, 1.20 MB

english, 1993

14

Reversible tyrosine phosphorylation and cell cycle control

Sue Atherton-Fessler, Gerhard Hannig, Helen Piwnica-Worms

Journal:

Seminars in Cell Biology

Year:

1993

File:

PDF, 587 KB

1993

15

Linaclotide is a potent and selective guanylate cyclase C agonist that elicits pharmacological effects locally in the gastrointestinal tract

Alexander P. Bryant, Robert W. Busby, Wilmin P. Bartolini, Etchell A. Cordero, Gerhard Hannig, Marco M. Kessler, Christine M. Pierce, Robert M. Solinga, Jenny V. Tobin, Shalina Mahajan-Miklos, Mitchel

Journal:

Year:

2010

Language:

english

File:

PDF, 391 KB

english, 2010

16

Cell Electrophoresis of Group B Streptococci: Separation of Types I a, Ib/c, II, III and IV Before and After Neuraminidase Treatment

Gerhard Uhlenbruck, Angelika Fröml, Rudolf Lütticken, Kurt Hannig

Journal:

Zentralblatt für Bakteriologie Mikrobiologie und Hygiene Series A Medical Microbiology Infectious Diseases Virology Parasitology

Year:

1988

Language:

english

File:

PDF, 656 KB

english, 1988

17

A tightly regulated high level expression vector that utilizes a thermosensitive lac repressor: production of the human T cell receptor Vβ5.3 in Escherichia coli

Beth Andrews, Hedy Adari, Gerhard Hannig, Elaine Lahue, Michael Gosselin, Sue Martin, Asma Ahmed, Pamella J. Ford, Edward G. Hayman, Savvas C. Makrides

Journal:

Year:

1996

Language:

english

File:

PDF, 998 KB

english, 1996

18

Gastrointestinal pain: Unraveling a novel endogenous pathway through uroguanylin/guanylate cyclase-C/cGMP activation

Silos-Santiago, Inmaculada, Hannig, Gerhard, Eutamene, Helene, Ustinova, Elena E., Bernier, Sylvie G., Ge, Pei, Graul, Christopher, Jacobson, Sarah, Jin, Hong, Liong, Elaine, Kessler, Marco M., Reza,

Journal:

Year:

2013

Language:

english

File:

PDF, 1015 KB

english, 2013

19

Linaclotide Inhibits Colonic Nociceptors and Relieves Abdominal Pain via Guanylate Cyclase-C and Extracellular Cyclic Guanosine 3′,5′-Monophosphate

Castro, Joel, Harrington, Andrea M., Hughes, Patrick A., Martin, Christopher M., Ge, Pei, Shea, Courtney M., Jin, Hong, Jacobson, Sarah, Hannig, Gerhard, Mann, Elizabeth, Cohen, Mitchell B., MacDougal

Journal:

Gastroenterology

Year:

2013

Language:

english

File:

PDF, 3.33 MB

english, 2013

20

Mo1752 Linaclotide Induces Endocytosis of the Sodium/Hydrogen Exchanger 3 (NHE3) and Inhibits Sodium Absorption

Ameen, Nadia, Jakab, Robert L., Hannig, Gerhard, Tchernychev, Boris, Arthur, David, Silos-Santiago, Inmaculada

Journal:

Gastroenterology

Year:

2014

Language:

english

File:

PDF, 66 KB

english, 2014

21

Structural and Spectroscopic Evidence for Intramolecular Agostic M···H−C and Dative Zr←F−C(ortho) Interactions in the Zwitterionic Metal Complexes [(C 5 H 4 )SiMe 2 (N-t-Bu)]M(+)(μ-C 4 H 6 )B(−)(C 6 F 5 ) 3 , M = Ti, Zr

Hannig, Frithjof, Fröhlich, Roland, Bergander, Klaus, Erker, Gerhard, Petersen, Jeffrey L.

Journal:

Organometallics

Year:

2004

Language:

english

File:

PDF, 160 KB

english, 2004

22

Carbamate Analogues of Fumagillin as Potent, Targeted Inhibitors of Methionine Aminopeptidase-2

Arico-Muendel, Christopher C., Benjamin, Dennis R., Caiazzo, Teresa M., Centrella, Paolo A., Contonio, Brooke D., Cook, Charles M., Doyle, Elisabeth G., Hannig, Gerhard, Labenski, Matthew T., Searle,

Journal:

Journal of Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 2.94 MB

english, 2009

23

Differential Gene Expression in B-Cell Non-Hodgkin's Lymphoma of SIV-Infected Monkey

Tarantul, Vyacheslav Z., Nikolaev, Alexey I., Martynenko, Alina, Hannig, Horst, Hunsmann, Gerhard, Bodemer, Walter

Journal:

AIDS Research and Human Retroviruses

Year:

2000

Language:

english

File:

PDF, 218 KB

english, 2000

24

Expression of the Human T-Cell Receptor Vβ5.3 in Escherichia coli by Thermal Induction of the trc Promoter: Nucleotide Sequence of the lacIts Gene

ADARI, HEDY, ANDREWS, BETH, FORD, PAMELLA J., HANNIG, GERHARD, BROSIUS, JÜRGEN, MAKRIDES, SAVVAS C.

Journal:

DNA and Cell Biology

Year:

1995

Language:

english

File:

PDF, 1.36 MB

english, 1995

25

Transforming Growth Factor beta Is a Growth-Inhibitory Cytokine of B Cell Lymphoma in SIV-Infected Macaques

Buske, Christian, Hannig, Horst, Schneider, Eva-Maria, Blaschke, Sabine, Hunsmann, Gerhard, Bodemer, Walter, Hiddemann, Wolfgang

Journal:

AIDS Research and Human Retroviruses

Year:

1999

Language:

english

File:

PDF, 240 KB

english, 1999

26

Mo1886 Regulation of Linaclotide-Induced cGMP and Electrolyte Secretion by Multidrug Resistance-Associated Protein 4 (MRP4)

Tchernychev, Boris, Ge, Pei, Wachtel, Derek, Solinga, Robert, Kessler, Marco, Ranganath, Sheila, Hannig, Gerhard, Silos-Santiago, Inmaculada

Journal:

Gastroenterology

Year:

2015

Language:

english

File:

PDF, 60 KB

english, 2015

27

Ein einfaches Verfahren zur Selektionierung von Mutanten

Braunitzer, Gerhard, Hobom, Gerd, Hannig, Kurt

Journal:

Hoppe-Seyler's Zeitschrift für physiologische Chemie

Year:

1964

Language:

german

File:

PDF, 394 KB

german, 1964

28

Zur Einheitlichkeit der Proteinstruktur

Braunitzer, Gerhard, Hobom, Gerd, Hannig, Kurt

Journal:

Hoppe-Seyler's Zeitschrift für physiologische Chemie

Year:

1964

Language:

german

File:

PDF, 377 KB

german, 1964

29

Die Einwirkung von Perjodsäure auf Prokollagen, II. Aminosäurenanalysen

Hörmann, Helmut, Hannig, Kurt, Fries, Gerhard

Journal:

Hoppe-Seyler's Zeitschrift für physiologische Chemie

Year:

1959

Language:

german

File:

PDF, 1.07 MB

german, 1959

30

A Fission-Yeast Gene Encoding a Protein with Features of Protein-Tyrosine- Phosphatases

Sabine Ottilie, Jonathan Chernoff, Gerhard Hannig, Charles S. Hoffman and R. L. Erikson

Journal:

Proceedings of the National Academy of Sciences

Year:

1991

Language:

english

File:

PDF, 970 KB

english, 1991

31

Negative Regulation of Mitosis in Fission Yeast by Catalytically Inactive pyp1 and pyp2 Mutants

Gerhard Hannig, Sabine Ottilie and Raymond L. Erikson

Journal:

Proceedings of the National Academy of Sciences

Year:

1994

Language:

english

File:

PDF, 1.55 MB

english, 1994

32

SPIE Proceedings [SPIE SPIE Medical Imaging - Lake Buena Vista, Florida (Saturday 12 February 2011)] Medical Imaging 2011: Image Processing - Detector defect correction of medical images on graphics processors

Membarth, Richard, Dawant, Benoit M., Haynor, David R., Hannig, Frank, Teich, Jürgen, Litz, Gerhard, Hornegger, Heinz

Year:

2011

Language:

english

File:

PDF, 2.21 MB

english, 2011

33

561 Chronic Oral Administration of the Guanylate Cyclase-C Agonist Linaclotide Attenuates Colitis Induced Bladder Afferent Hyperactivity

Grundy, Luke A., Garcia-Carraballo, Sonia, Maddern, Jessica, Rychkov, Grigori, Hannig, Gerhard, Kurtz, Caroline B., Silos-Santiago, Ada, Brierley, Stuart

Journal:

Gastroenterology

Year:

2016

Language:

english

File:

PDF, 152 KB

english, 2016

34

MP28-06 COLITIS INDUCES LONG-TERM BLADDER AFFERENT HYPERACTIVITY, WHICH IS ATTENUATED BY CHRONIC ORAL ADMINISTRATION OF THE GUANYLATE CYCLASE-C AGONIST LINACLOTIDE

Grundy, Luke, Garcia-Caraballo, Sonia, Maddern, Jessica, Rychkov, Grigori, Hannig, Gerhard, Kurtz, Caroline, Silos-Santiago, Ada, M. Brierley, Stuart

Journal:

The Journal of Urology

Year:

2016

Language:

english

File:

PDF, 199 KB

english, 2016

35

366 Guanylate Cyclase-C Expression Is Down-Regulated in Colonic Biopsies From Female Irritable Bowel Syndrome Patients With Constipation

Garcia-Carraballo, Sonia, Harrington, Andrea, Castro, Joel, Hannig, Gerhard, Kurtz, Caroline B., Silos-Santiago, Ada, Chang, Lin, Brierley, Stuart

Journal:

Gastroenterology

Year:

2016

Language:

english

File:

PDF, 690 KB

english, 2016

36

Genetic basis of allochronic differentiation in the fall armyworm

Hänniger, Sabine, Dumas, Pascaline, Schöfl, Gerhard, Gebauer-Jung, Steffi, Vogel, Heiko, Unbehend, Melanie, Heckel, David G., Groot, Astrid T.

Journal:

BMC Evolutionary Biology

Year:

2017

Language:

english

File:

PDF, 1.66 MB

english, 2017

37

Inhibition of melanoma tumor growth by a pharmacological inhibitor of MetAP-2, PPI-2458

Hannig, Gerhard, Lazarus, Douglas, Bernier, Sylvie, Karp, Russell, Lorusso, Jeanine, Qiu, Daniel, Labenski, Matthew, Wakefield, Jim, Thompson, Charles, Westlin, William

Journal:

International Journal of Oncology

Year:

2006

Language:

english

File:

PDF, 219 KB

english, 2006

38

Linaclotide activates guanylate cyclase‐C/cGMP/protein kinase‐II‐dependent trafficking of CFTR in the intestine

Ahsan, Md. Kaimul, Tchernychev, Boris, Kessler, Marco M., Solinga, Robert M., Arthur, David, Linde, Cristina I., Silos‐Santiago, Inmaculada, Hannig, Gerhard, Ameen, Nadia A.

Journal:

Physiological Reports

Year:

2017

Language:

english

File:

PDF, 2.85 MB

english, 2017

39

Extracellular CGMP Reduces the Excitability of Sensory Dorsal Root Ganglion Neurons via an Extracellular Mechanism

Grundy, Luke A., Castro, Joel, Harrington, Andrea, Peters, Stefanie, Feil, Robert, Miller, Paul, Ghetti, Andre, Hannig, Gerhard, Kurtz, Caroline, Silos-Santiago, Ada, Brierley, Stuart

Journal:

Gastroenterology

Year:

2017

Language:

english

File:

PDF, 252 KB

english, 2017

40

Chronic Oral Administration of Linaclotide Inhibits Nociceptive Signalling in Response to Noxious Colorectal Distension in a Model of Chronic Visceral Hypersensitivity

Castro, Joel, Deiteren, Annemie, Harrington, Andrea, Maddern, Jessica, Moore, Jessi, Garcia-Caraballo, Sonia, O'Donnell, Tracey, Grundy, Luke A., Hannig, Gerhard, Kurtz, Caroline, Silos-Santiago, Ada,

Journal:

Gastroenterology

Year:

2017

Language:

english

File:

PDF, 223 KB

english, 2017

41

Linaclotide Attenuates Visceral Organ Crosstalk: Importance of Guanylate Cyclase C (GC-C) Activation in Reversing Colonic Hypersensitivity Induced by Urinary Bladder Hyperpermeability

Mohammadi, Ehsan, Ligon, Casey O., Ge, Pei, Hannig, Gerhard, Kurtz, Caroline, Meerveld, Beverley Greenwood-Van

Journal:

Gastroenterology

Year:

2017

Language:

english

File:

PDF, 888 KB

english, 2017

42

MP42-05 CHRONIC ORAL ADMINISTRATION OF THE GUANYLATE CYCLASE-C AGONIST LINACLOTIDE ATTENUATES COLITIS INDUCED BLADDER AFFERENT AND DORSAL ROOT GANGLION HYPERACTIVITY

Grundy, Luke, Garcia-Caraballo, Sonia, Maddern, Jessica, Rychkov, Grigori, Ge, Pei, Hannig, Gerhard, Kurtz, Caroline, Silos-Santiago, Ada, Brierley, Stuart

Journal:

The Journal of Urology

Year:

2017

Language:

english

File:

PDF, 340 KB

english, 2017

43

Oral Administration of the Gut-Restricted Guanylate Cyclase-C Agonist, Linaclotide, Reduces Endometriosisinduced Vaginal Hyperalgesia

Ge, Pei, Ren, Jingmei, Silos-Santiago, Ada, Kurtz, Caroline, Hannig, Gerhard

Journal:

Gastroenterology

Year:

2017

Language:

english

File:

PDF, 347 KB

english, 2017

44

Linaclotide-induced electrolyte secretion in human and rat colon: Ussing chamber studies

Tchernychev, Boris, Hannig, Gerhard, Arthur, David, Ge, Pei, Tobin, Jenny, Silos-Santiago, Inmaculada

Journal:

BMC Pharmacology and Toxicology

Year:

2015

Language:

english

File:

PDF, 205 KB

english, 2015

45

Linaclotide Attenuates Visceral Organ Crosstalk: Role of Guanylate Cyclase C Activation in Reversing Bladder-Colon Cross Sensitization

Mohammadi, Ehsan N, Ligon, Casey O., Silos-Santiago, Ada, Ge, Pei, Kurtz, Caroline, Higgins, Carolyn, Hannig, Gerhard, Greenwood-Van Meerveld, Beverley

Journal:

Journal of Pharmacology and Experimental Therapeutics

Year:

2018

Language:

english

File:

PDF, 7.28 MB

english, 2018

46

1017 - Guanylate Cyclase 2C Activation Rescues the Folding Defect in F508Del CFTR

Arora, Kavisha, Kessler, Marco, Hannig, Gerhard, Naren, Anjaparavanda P.

Journal:

Gastroenterology

Year:

2018

Language:

english

File:

PDF, 189 KB

english, 2018

47

Mo1515 - Bile Acid Sequestrant Shows Effects on the Contractile Activity of Ex Vivo Lower Esophageal Sphincter Muscle

Jacobson, Sarah, Hannig, Gerhard, Silos-Santiago, Ada, Currie, Mark

Journal:

Gastroenterology

Year:

2018

Language:

english

File:

PDF, 494 KB

english, 2018

48

Guanylate cyclase-C/cGMP: an emerging pathway in the regulation of visceral pain

Hannig, Gerhard, Tchernychev, Boris, Kurtz, Caroline B., Bryant, Alexander P., Currie, Mark G., Silos-Santiago, Inmaculada

Journal:

Frontiers in Molecular Neuroscience

Year:

2014

Language:

english

File:

PDF, 527 KB

english, 2014

49

The Soluble Guanylate Cyclase Stimulator IWP-953 Increases Conventional Outflow Facility in Mouse Eyes

Ge, Pei, Navarro, Iris D., Kessler, Marco M., Bernier, Sylvie G., Perl, Nicholas R., Sarno, Renee, Masferrer, Jaime, Hannig, Gerhard, Stamer, W. Daniel

Journal:

Investigative Opthalmology & Visual Science

Year:

2016

Language:

english

File:

PDF, 1006 KB

english, 2016

50

Sa1681 – Gc-C Agonism with Linaclotide Attenuates Chronic Stressinduced Colonic Hypersensitivity Independently of Elevated Crf Expression in the Central Nucleus of the Amygdala

Ligon, Casey O., Hannig, Gerhard, Ge, Pei, Higgins, Carolyn S., Meerveld, Beverley Greenwood-Van

Journal:

Gastroenterology

Year:

2019

Language:

english

File:

PDF, 46 KB

english, 2019

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